Home to Harvard University and the Massachusetts Institute of Technology, Cambridge sits directly across the Charles River from downtown Boston and serves as the core of Greater Boston’s reputation as an intellectual powerhouse. These academic institutions, and the many research institutions that surround them, fuel the Massachusetts innovation economy and spawn Nobel Prize winners, high technology start-ups, and life science companies at an amazing rate. Cambridge may well be the most prominent life science market in the world, with local companies including Biogen, Millennium Pharmaceuticals, and Genzyme, as well as International firms such as Novartis occupying large facilities. Established technology firms, as well as venture capital, consulting, and a diverse array of other service firms also call Cambridge home to gain access to Cambridge’s highly educated workforce and unique urban culture. Submarkets within Cambridge are East Cambridge, the largest, Harvard Square, a niche but very desirable cluster around Harvard University, and Alewife Station/Route 2, which has developed around the Red Line MBTA station in West Cambridge.